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Studies show CBD may help relieve chronic pain and inflammation

March 14, 2018 151 Comments

Help Relieve Chronic Pain and Inflammation with CBD

Studies on CBD oil and pain management have shown a great deal of promise. CBD can also offer an alternative for people who have chronic pain and rely on more dangerous, habit-forming medications, such as opioids. 

Cannabidiol (CBD) as you know by visiting this site, is a pain relieving cannabinoid found in the cannabis plant that doesn’t induce the psychoactive properties of its THC brethren. Furthermore, CBD’s non-addictive attribute makes it the preferred substance for pain relief over many opioids.

 

CBD Regulates Cytokine Production in Immune Cells

One of its most significant and commonly used method for pain relief is its potential as an anti-inflammatory agent. As illustrated in a US National Library of Medicine & National Institutes of Health study,

“Cytokines are the signaling proteins synthesized and secreted by immune cells upon stimulation. They are the modulating factors that balance initiation and resolution of inflammation. One of the possible mechanisms of immune control by cannabinoids during inflammation is the dys-regulation of cytokine production by immune cells and disruption of the well-regulated immune response.”

In other words, cytokines regulate the immune system by either initiating or resolving inflammation. If a person experiences chronic inflammation, then it’s because their cytokines are out of balance, which CBD helps to regulate.

 

CBD Lessens the Impact of Inflammation on Oxidative Stress

According to another US NLM & NIH study,

“Oxidative stress with reactive oxygen species generation is a key weapon in the arsenal of the immune system for fighting invading pathogens and initiating tissue repair. If excessive or unresolved, however, immune-related oxidative stress can initiate further increasing levels of oxidative stress that cause organ damage and dysfunction.Targeting oxidative stress in various diseases therapeutically has proven more problematic than first anticipated given the complexities and perversity of both the underlying disease and the immune response. However, growing evidence suggests that the endocannabinoid system, which includes the CB and CB G-protein-coupled receptors and their endogenous lipid ligands, may be an area that is ripe for therapeutic exploitation. In this context, the related nonpsychotropic cannabinoid cannabidiol, which may interact with the endocannabinoid system but has actions that are distinct, offers promise as a prototype for anti-inflammatory drug development.

Similar to the above imbalance with cytokines, here we’re seeing that oxidative stress can cause organ damage or dysfunction, but can again be regulated by CBD.

 

CBD Reduces Intestinal Inflammation by Controlling Reactive Gliosis

In a 2011 study, it was found that,

“CBD targets enteric reactive gliosis, counteracts the inflammatory environment induced by LPS in mice and in human colonic cultures derived from UC patients. These actions lead to a reduction of intestinal damage mediated by PPARgamma receptor pathway.Our results therefore indicate that CBD indeed unravels a new therapeutic strategy to treat inflammatory bowel diseases.

Enteric glial cells (EGC) mediate acute and chronic inflammation in the stomach, and when these go out of whack they amplify the response in the Central Nervous System and immune systems. As stated in the study, “CBD is an interesting compound because of its ability to control reactive gliosis in the CNS, without any unwanted psychotropic effects[emphasis added].”

We at PureKana also think CBD is interesting! If you’re suffering from chronic inflammation, then check out our oilstopicalsgummies, and capsules to reduce your pain in a non-psychoactive way!

 

PureKana shall not be held liable for the medical claims made by customer testimonials. The statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products and the testimonials made have not been confirmed by FDA- approved research. These products are not intended to diagnosis, treat, cure or prevent any disease. All information presented here is not meant as a substitute for or alternative to information from health care practitioners. Please consult your health care professional about potential interactions or other possible complications before using any product. The Federal Food, Drug and Cosmetic Act requires this notice.


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151 responses
  1. I have had very bad nerve damage pain from shingles for a couple of years and facial nerve pain. I have been using your oil for a couple of months. Right now I am taking your cbd oil 1000mg 1-2 times a day for my pains. It seems to me that it does quite help alleviate my pain but it does help my chronic neck and shoulder pain. Do I need to increase my dosage for my nerve damage pain? I learned once I have shingles, it stays in my system forever. No medications even cbd oil can help me get rid of it. Is it true even cbd oil can’t do it? Pls advise.

    1. Hello,

      There have been studies on CBD and shingles, you can slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed, you can also apply the oil or topical to the specific area and that may help as well.

  2. Hi there friends, how is the whole thing, and what you wish for to say on the topic of this post, in my view its in fact amazing in support of me.

  3. Is there any reason using the oil topically instead of the salve would not absorb well? I use it on my arms for suppression of those annoying but not deadly sun cancers, even with surgery they come back and spread, i alternate with prescription Retin A and your CBD oil applied to my arms, Adding the cbd has noticeably reduced the rate ant grow or reappear and checked the spread of new ones, i had read CBDs benefit in cancer cases stopping/slowing spread so i gave the oil a try, The oil absorbed so fast and is so creamy and luxurious on the skin i admit i often add to moisturizing skin care on neck and face,

    i’ve been and my dog also, using your natural flavor oils, i prefer to other brands i have tried, It certain;y got my attention when i put a few drops on a raging tooth ache, Immediately the ten on a scale of ten was cut in half, i continued woth a few drops of the oil directly on the tooth every couple hours, broken and showing signs of infection. It wasn’t just oil covering the nerve temporarily. the tooth ache in a tooth messed up and needing removal, after several days application and occasional touch up, i have had no pain in that tooth. Perhaps i think it was helped on a number of levels the pain, inflammation, resetting the over reactive nerve pain the tooth had started. Could be an excellent addition to first aid kits and disaster bug-out bags .for emergency tooth ache relief.

    i’m wondering how much when oil is topically applied can reach my blood system and work systematically for other issues? i gave heard ingesting cbds one gets a lesser percent of mgs than under the tongue so i’m wondering if oil is used on skin how much of the dose goes into the blood approximately?

    An added benefit using on my arm, putting on my wrist which was badly broken and repaired resulting in ongoing swelling soreness redness, the oil soothed the wrist joint not just masked pain. The topicals would not provide a high enough dose or be far too costly for my purposes. Plus the oil provides substantial relief for my wee mutt in skin issues, anxiety and knee hip pain, No limping with the oil. It is hard to afford both our uses however, If it came down to it i’d limit mine so she could have what she needs .

    i only see discounts from companies for technically “disabled” with paper work . Elders on a fixed income don;t, drs do not declare elders as disabled since they aren’t working. i’d like to be able to afford both my puppies and my best use of cbd. And i prefer Pure Kana to other brands of cbd alone. and mail order is cheaper than legal dispensary limited choice of products. ( i do like the 1 to 1 with thc from dispensary but too expensive.)
    Your customer service is super, that keeps me returning,

    1. Hello,

      Thank you for your wonderful feedback and your kind words! We love to hear you and your pup are both getting relief. Our oils are designed for sublingual use meaning the drops are placed under the tongue for 60-90 seconds before swallowing and metabolize through the bloodstream. When applied to your skin, the oils absorb into the skin and can help give relief that way as well.

  4. I have IBD’s /Crohns disease will it help this, I do have joint pain from the infusion medicine that I have to take every 6 weeks.
    Gina

    1. Hello,

      The 1000mg potency would be best. The recommended dose is 1/2 the dropper 1-2 times a day. If you do not get the desired relief within a couple days you can slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. Our products metabolize differently in each individual; we do have customers whom take it in the morning, afternoon, and evening as they find that is what works best for them.

  5. Have heard CBD could be effective for weight control. So, which product and dosage would be effective? I will be trying tablets for reduced inflammatory in hands etc.,

    1. Hello Rebecca,

      The 600mg would be the best. The recommended dose is ½ the dropper 1-2 times a day. If you do not get the desired relief within a couple days you can slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. Our products metabolize differently in each individual; we do have customers whom take it in the morning, afternoon, and evening as they find that is what works best for them.

    1. Hello,

      For chronic pain the 1000mg potency is best. The topical ointment may be beneficial as well as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

    1. Hello,

      We do not have any products that contain anymore THC. At this time the 1000mg is our strongest potency. The recommended dose is ½ the dropper 1-2 times a day. If you do not get the desired relief within a couple days you can slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. Our products metabolize differently in each individual; we do have customers whom take it in the morning, afternoon, and evening as they find that is what works best for them. The topical ointment may be beneficial as well as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  6. I bought the 300mg and I can’t feel any relief. If I took a whole dropper would that change the mg dosage and if so what would it be? I will buy the 1000 next time. Can I take 3 droppers full to get around 1000mg or does it not work that way?

    1. Hello,

      The recommended dose is ½ the dropper 1-2 times a day. If you do not get the desired relief within a couple days you can slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. Our products metabolize differently in each individual; we do have customers whom take it in the morning, afternoon, and evening as they find that is what works best for them.

  7. I received the PureKana oil in late July. Am hoping that it will relieve my painful right foot. (diabetic neuropathy). Also hope that it will decrease or eliminate residual shingles pain. So far, no noticeable improvement. Started out using 15 drops per day to determine if I had any bad reaction to CBD oil. Now using two full eye dropper doses and still do not feel any improvement. Is there a better method to use than sublingual ingestion?

    1. Hello,

      I am very sorry to hear this Neal. 🙁 A stronger potency is best for chronic pain and the topical ointment would be beneficial as well.

  8. I have a non union hip after a pinning and the pain is terrible. Can’t do Physical Therapy because of pain. Will this help?

    1. Hello,

      For chronic pain the 1000mg potency is best. The recommended dose is ½ the dropper 1-2 times a day. If you do not get the desired relief within a couple days you can slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. Our products metabolize differently in each individual; we do have customers whom take it in the morning, afternoon, and evening as they find that is what works best for them. The topical ointment may be beneficial as well as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  9. I have been suffering with phantom smell disorder since March of this year and have been seeing on some blogs that similar folks have had luck using full spectrum oil. Do you have any info/experience dealing with this. I take other meds for other issues so would definitely ask my Dr before using. Not taking any meds for this disorder as the ENT’s are saying it will just have to resolve. Tired of everything smelling/tasting like smoke or kerosene. I’m ready to try about anything!

    1. Hello,

      The 600mg potency would be a good place to start. The recommended dose is ½ the dropper 1-2 times a day. If you do not get the desired relief within a couple days you can slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. Our products metabolize differently in each individual; we do have customers whom take it in the morning, afternoon, and evening as they find that is what works best for them.

  10. I am a Registered Nurse. I have random drug testing ay my hospital. Does the CBD oil that you sell with the low THC still show up in a Urine Drug Screen? I have severe osteoarthritis from head to toe and have multiple cervical vertebra fusions done already. I take Tramadol 100mg 4 times a day just to keep the pain down enough to function. I’m not interested in narcotic pain relief and I don’t want to take anything that would end my career due to a positive drug screen either. I just would like to live with a little less pain everyday.

    1. Hello Terry,

      Our full spectrum products do contain .02% THC. We can not guarantee you will or will not pass a drug test as every drug screen is different. We will be adding THC FREE oils soon and our gummies and purepicks are currently THC Free.

  11. I have lymphedema in my legs and feet, and now moving into torso area.. will this help with the swelling and pain?

    1. Hello,

      For chronic pain the 1000mg. potency is best. The recommended dose is 1/2 the dropper 1-2 times a day. If you do not get the desired relief within a couple days you can increase the dose as that is not harmful and essentially adds to the potency being absorbed. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. The topical ointment may be very beneficial as well as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

    1. Hello,

      Our full spectrum products do contain .02% THC, we can not guarantee you will or will not pass a drug test as every drug screen is different. We will have THC FREE oils soon and our gummies and purepicks are currently THC FREE.

  12. Started CBD oil 250 mg three days ago 1/2 dropper twice a day for hip pain (bursitis). After reading comments from customers I wanted to try 1000mg oil but am having loose stools. Should I?

    1. Hello Betty,

      I am very sorry to hear that, our products do metabolize differently in each individual. It could be the brand you are taking maybe something in the ingredients. Our products are organic and have all natural flavoring. The 1000mg. is best for chronic pain and the topical ointment is also wonderful as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  13. I suffer with idiopathic chronic hives and was wondering if this product will work and what dosage should I take.

    1. Hello,

      The topical ointment contains menthol so it gives an instant relief while the CBD absorbs into the skin. If you would like to try the oil as well I would start with the 600mg. and take only 1/4 the dropper 1-2 times a day to begin with.

  14. I have hidradentitis supparitiva a very painful skin condition. What mg would I need to order and would I put it directly on the sores or ingest?

    1. Hello Pam,

      Our oils would be best and maybe the topical ointment as well! The oils are designed for sublingual use and I would recommend the 600mg. starting with 1/4 the dropper 1-2 times a day. The topical contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  15. I placed my order on the 21st and hope the CBD oil will help with lower lower back pain.Pulled the L.4 and L.5 removing clothes out of the dryer March 15,2018.I have an RX for Tramadol 50 m.g and Acetaminophen-codeine 30 m.g..I have had 3 shots in my spine by a Pain Specialist but they don’t last.Hope the 300 works for me but I read you recommend mostly 1000 m.g.CBD.I am looking forward to trying your oil.

    1. Hello,

      Keep in mind if the 300mg. does not work for you at the recommended dose you can increase the dose to reach desired relief. 🙂 If you have any questions let us know! 🙂

    1. Hello,

      CBD has many wonderful health benefits. CBD may help your system so you do not get UTIs, however, we can not guarantee it.

  16. Do you have any plans to make your oil in a higher strength, like 1500 mg? I have to take at least 25 mg ev. 4 hours, and want to experiment with slowly increasing the dose to see if I can get more relief. I switched from medical marijuana to CBD oil from hemp because of the expense. I use it for chronic pain, the ongoing effects of three failed back surgeries, and severe stenosis. One goes through these small bottles very quickly.

    Thanks.

    1. Hello,

      We do have plans to get higher potencies! 🙂 The topical ointment may help you out as well; let us know if we can assist you with anything else.

  17. My husband has constant nerve pain that goes from his back down his leg. He has stabbing pain and burning pain we have tried everything there is for nerve pain to no avail. It interferes with his sleep often keeping him up at night. Was told about CBD oil. He is diabetic so I am wondering if this is safe for him and what dosages would be best for him to take was thinking about giving him both the oral oil as well as getting the topical for him to rub into his knee. I need to find something that works he has been struggling with this for almost a year

    1. Hello,

      For chronic pain the 1000mg potency is best. The recommended dose is 1/2 the dropper 1-2 times a day, if you do not get the desired relief within a day or two, slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. The drops are placed under your tongue for 60-90 seconds before swallowing and metabolize through the blood stream. The topical ointment would be wonderful as well as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  18. I have severe migraines & SI Joint problems. What do you recommend that I get for my pain? I’ve tried 250 plus CBD oil from another company but really didn’t feel much difference. I don’t like taking so much medications all the time because I only have one kidney.

    1. Hello,
      For chronic pain the 1000mg potency is best. The recommended dose is 1/2 the dropper 1-2 times a day, if you do not get the desired relief within a day or two, slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. The drops are placed under your tongue for 60-90 seconds before swallowing and metabolize through the blood stream.

    1. Hello,

      Yes, the 1000mg potency oil or capsules would be the best. 🙂 The topical ointment would be beneficial for ay sore muscles and aches as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  19. HI,I am going to talk to Doctors in two weeks. I am a heart transplant survivor , do you know if you have any customers with the same condition?
    Thanks

    1. Hello,

      I apologize, we have many customers and not all of them tell us what they are looking to treat. CBD has many wonderful health benefits though!

  20. Afraid if I order this product I could not have a good chance to have a normal life I’ve spent so much money already lookin for help please

    1. Hello Billie,

      We do offer a 30day return and refund if you are not satisfied with the product. Please feel free to emails us and we may be able to help give you a recommendation! 🙂

  21. Do you have vapinig cartridges and what milligram would you recommend for severe knee pain. I know you only have 0.02 THC. I tried an 80%CBD 20% THC that was excellent. Being in chonic pain tents to make me tense, the 20% THC doesn’t get me high, but relaxes me. CBD takes away the pain. Do you have these items available?

    1. Hello,

      We will be adding vape products soon! 🙂 For chronic pain the 1000mg. is best. The recommended dose is 1/2 the dropper 1-2 times a day, if you do not get the desired relief within a day or two, slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. The drops are placed under your tongue for 60-90 seconds before swallowing and metabolize through the blood stream.The topical ointment is also wonderful as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  22. The Dr suggested my husband use CBD for his pain and to get him off opioid he has used for 18+ years for his back injury at work. He is permanately disabled and is in terrible pain with out his pain pills he also is a diabetic and legs and feet hurt all the time. He can’t sleep and has a lot of headaches would this help him have a descent life

    1. Hello,
      The 1000mg. potency would be best! The recommended dose is 1/2 the dropper 1-2 times a day. The drops are placed under the tongue for 60-90 seconds before swallowing and metabolize through the bloodstream. If you do not get the desired relief within a day or two you can slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. Our products do metabolize differently in each individual, we do have customers who take it in the morning, afternoon, and evening as they find that is what works best for them.

  23. How much do I take for anxiety and depression, and does it come in the isolate form and what’s the price, also do u get same results in isolate form.

    1. Hello,

      It is best to start low and increase if/as needed. The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed. We will have isolate based oils soon, due to our products metabolizing differently in everyone, some individuals get awesome relief with isolates and some do not. You can view all products and prices at purekana.com 🙂

  24. I have severe fibromyalgia pain and take hydrocodone. I don’t sleep well. Can I take cbd oil to help me get off opiod. will it help me sleep I would like to order 1000 I work and want to know if it will make me tired during the day,

    1. Hello,

      For chronic pain and insomnia the 1000mg. potency is best. It shouldn’t make you physically tired. The topical ointment is wonderful as well due to it containing menthol so it gives an instant relief while the CBD absorbs into the skin. We do recommend speaking with a physician before ingesting with other medication.

  25. CBD sounds wonderful, like the solution I’ve dreamed of for yours. Decades. With just one catch — THC. Now, I understand it’s limited, but I the only mind-altering effect I want is pain relief. I’m sure the effect on everyone differs, but it’s not cheap to find out how it affects me. Can you speak to that concern, and do you offer any return policy? Thank you.

    1. Hello,

      Even though our full spectrum products contain .02% THC, they do not get you high and there are no psychoactive affects. We do have a 30day return and refund policy! 🙂 For chronic pain the 1000mg. potency is best. The topical ointment is also wonderful as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  26. Looking for medical studies: I have deep stabbing ear pain from TMJ, degenerative arthritis in my jaw, and suffer from intermittent hyperacusis. I can’t tolerate menthol. Looking for information to share with my neurosurgeon for CBD oil success stories. A blog won’t do.

    1. Hello,

      I apologize, our products metabolize differently in each individual, we do not have medical studies except for the many articles that we read on CBD and its benefits along with studies that have been done. You may be able to google what you need and find it on WebMD or other reliable websites that contain wonderful studies showing the many benefits of CBD.

  27. I have planters fasciitis which is very painful. I am doing exercises and icing but the pain is unbearable…will CBD give relief for this type of pain?

    1. Hello,

      CBD helps many different things, chronic pain is one of them! For chronic pain the 1000mg. is best! The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed.

  28. Hello,
    I bought some oil and ointment coming soon. I also bought from another company GAB before I found you! Dont hate me. It is 1500mg. I want to use it for both joint pain in big toe and shoulder and sleep. What do you recommend for sleep with the 1500mg and what do you recommend for the 300mg that I bought from you? (Both pain and sleep) I see you usually recommend 1000mg for pain but I did not purchase 1000 for it says to start with a low dosage….? I am confused. Help please?

    1. Hello,

      For chronic pain the 1000mg. is best! The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed. The topical ointment is also wonderful as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

      For the other product you purchased, they should have a recommended dose on their bottle; as every company is different and the products are different, I recommend reaching out to them. I apologize for the inconvenience.

  29. Help me, I’M A CONTAMINATED VETERAN BY DRINKING TOXIC WATER FOR MONTHS WITHOUT EVEN KNOWING IT. NO MEDICAL TREATMENT TO THIS DATE SINCE MY INTAKE IN 1974. WHAT IS THE BEST MEDICAL STENGHT TO ELIMINATE SEVERE PAIN, HEADACHES, STOMACH DISORDERS, BODY BLISTERS & RASHES, SWELLING WITH SEVERE BODY PAIN. SLOW DEATH NEED HELP ASAP!!!

    1. Hello,

      For chronic pain the 1000mg. potency is best. The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed.The drops are placed under your tongue for 60-90 seconds before swallowing. The oils can be applied topically as well. We also have a topical ointment which contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  30. My husband has severe pain in his thumbs because of arthritis and deterioration of connective tissue: bone pressing on bone.

    Have any of your clients used the oil for this condition, and if so, what were the results? Would you recommend the oil for him, and if so, at what strength and how often?

    1. Hello,
      For chronic pain the 1000mg. potency is best. The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed.The drops are placed under your tongue for 60-90 seconds before swallowing. We also have a topical ointment which contains menthol so it gives an instant relief while the CBD absorbs into the skin.

      We have many customers whom use our products for chronic pain, arthritis, etc. and they get wonderful relief. Our products do metabolize differently in each individual, and if he is not satisfied, we do have a 30day return and refund policy.

  31. I was wondering how often the pricing of products fluctuate. I just notices a $6 increase on a recent item I just ordered… can anyone advise. Thank you.

    1. Hello,

      The only time our prices change are if we have a sale going, so when we do sales we don’t always announce a discount code as the discount is already applied to the price. I apologize for the inconvenience.

  32. I’d like to try your product to relieve painful inflammation in the joints of my fingers due to rheumatoid arthritis. What dosage do you suggest I start with?

    1. Hello,
      For chronic pain the 1000mg. potency is best. The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed. The drops are placed under your tongue for 60-90 seconds before swallowing. We also have a topical ointment which contains menthol so it gives an instant relief while the CBD absorbs into the skin.

    1. Hello,

      The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed.

  33. I suffer with crohn’s, IBS, and G.E.R.D. will this help me alleviate my pains and intestinal inflammations?

    1. Hello,

      The 1000mg. potency would be best. The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed. We also have a topical ointment which contains menthol so it gives an instant relief while the CBD absorbs into the skin. If you are not satisfied with the product, please reach out as we do have a 30day return and refund policy. Sign up for the email subscription to receive discount codes!

  34. am on hormone blocker after breast cancer surgery and treatments is it ok to take cbd for pain and depression? what kind and price

    1. Hello,

      We do recommend speaking with a physician before ingesting with other medication. It is best to start low and increase if/as needed. You can view all products and prices at purekana.com 🙂

    1. Hello,
      For chronic pain the 1000mg. potency is best. The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed. We also have a topical ointment which contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  35. I have RA, Fibromyalgia, Osteoporosis, Peripheral Neuropathy, Bipolar, Depression, @ Was on Fentanyl 150mg, Morphine 200mg 3x a day, Oxycodone,Oxycotin, Lortabs,Xanax 1g 4 xs a day @ others for years Sept 2006 my liver@ kidneys shut down, @ other things wrong was in hospital over a month 3 different floors I was on.
    Was in hospital 3 other times 4 same thing. the 3rd time in hospital Dr or whoever took me off all narcotics needless to say I was FUCKEN pissed they didn’t tell me at all talked @ withdraw for a month or better, family would go to Dr with me make sure Dr wouldnt give me no narcotics…I started CBD oil, gummies, vape pen, @ others in Dec.2016 I would like to know what mg I should be on I now have CBD 3 mg @ 10 mg of CBD Cap’s,@ smoke..
    I Apologized for going on.. The CBD does help some I take am.after noon @ pm.

    1. Hello,

      For chronic pain the 1000mg. potency is best. The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed. The drops are placed under the tongue for 60-90 seconds before swallowing. We also have a topical ointment which contains menthol so it gives an instant relief while the CBD absorbs into the skin. If you are not satisfied with the product, please reach out as we do have a 30day return and refund policy. Sign up for the email subscription to receive discount codes!

    1. We do ship to Ireland! 🙂 The 600mg. would be a good place to start! The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed. Please keep in mind that sometimes more is less so by that I mean if you are absolutely not getting any relief, the dose may be too high; try to lower the dose for a couple days and then slowly increase until relief has been reached. 🙂 If you have any questions please reach out via email or faceboook.

    1. Hello,

      I recommend starting with the 600mg. potency. The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed.

  36. Hello!
    I just purchased the CBD 1000 mg oil for chronic pain. I have severe nerve damage in my foot (I do not have diabetes) from overuse. I just don’t know how many drops to take a day. I weigh 133 pounds. Could you please give me a suggestion?

    1. The recommended dose is 1/2 the dropper 1-2 times a day. I do recommend trying to start out with about 1/4 the dropper. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed.

    1. Hello,

      For chronic pain the 1000mg. potency is best. The recommended dose is 1/2 the dropper 1-2 times a day. Our products do metabolize differently in each individual so we do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. If you do not get the desired relief within a day or two you can increase the dose as that is not harmful and essentially adds to the potency being absorbed.

      The purepicks may help wonderfully as well!

  37. CBD oil, orally, does work! I started with the 300mg bottle & it just didn’t help. I have OA, OP & severe chronic back pain due to a broken back & much deterioration. So I recently upped my dose to the 600mg bottle. It has noticeably helped. I am 77 yrs. old & feel I have finally found some relief for pain I have been fighting for fifteen years. Thank you PureKana

    1. Hello,

      We do ship to the UK! It takes approximately 1-5 business days to fulfill an order and 1-4 for USPS to deliver! 🙂

  38. Is your CBD from organic hemp?
    Domestic grown or what country?
    By what process is it extracted? Is your CBD oil tested by an independent lab?

    1. Hello,

      Our plants are organically grown in Kentucky. Each batch is tested to ensure potency and we use a Co2 Extraction method.

  39. How well does CBD oil work for elderly people? I have a 93 year old father with degenerative arthritis in his lower back. Are dosages based on body weight or are dosages standard? Are there any other issues to be aware of for geriatric patients?

    1. Hello,

      We do recommend speaking with a physician before ingesting with other medications. Recommend he start with the 600mg. potency. The recommended dose is 1/2 the dropper 1-2 times a day. If he does not get the desired relief within a day or two he can increase the dose as that is not harmful and essentially adds to the potency being absorbed. He can find what works best for him so if he finds that taking it in the morning and evening isn’t enough he can take it in the afternoon as well; our products metabolize differently in each individual. We also have a topical ointment which contains menthol so it gives an instant relief while the CBD absorbs into the skin.

    1. Hello,

      For chronic pain we recommend the 1000mg. potency. Our topical ointment is also wonderful as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  40. What would be the best oil for severe fibromyalgia pain. I do work where I am drug tested randomly, so I need to know if these oils would test positive

    1. Hello,

      PureKana can not guarantee you will or will not pass a drug test as every drug screen is different. Our full spectrum products do contain .02% THC. We will be adding isolate based oils soon! The topical ointment is wonderful as it contains menthol so it gives an instant relief while the CBD absorbs into the skin. The best potency oil for chronic pain is the 1000mg. potency which is 25mg. per dose.

    1. For chronic pain we recommend the 1000mg potency. It takes approximately 1-5 business days to fulfill an order and 1-4 days for USPS to deliver. You can shop on the site! 🙂

    1. Hello,

      We have many customers whom use it for neuropathy and chronic pain. I recommend the 1000mg. potency as it is best for chronic pain. The topical ointment would be good as well as it contains menthol so it gives an instant relief while the CBD absorbs into the skin. 🙂

    1. Hello,

      PureKana can not guarantee you will or will not pass a drug test using our full spectrum products as they do contain .02% THC. We do have isolate based, meaning no THC, oils that will be available soon! Currently we have the gummies and the purepicks which are both isolate based! 🙂

  41. I got your email concerning cbd and sleep. The report contradicted itself, first saying that it would help sleep, then in the next paragraph stating it improved wakefulness, and inhibited REM sleep. Which is it?

    1. Hello Robert,

      Our products metabolize differently in each individual. They don’t necessarily make you tired, however, they do help insomnia.

  42. How long does it take before I feel some results to a lower pain threshold?
    I just started three days ago and I’m taking g half dropper full 2 x daily of 300mg?0

    1. Hello Arlene,

      Our products metabolize differently in each individual. For pain we normally recommend a higher potency, try to increase the dose to a full dropper twice daily. We do have customers who take it in the morning, afternoon, and evening as they found that is what works best for them. It is not harmful to increase the dose as it essentailly just adds to the potency being absorbed.

  43. I am a victim of multi back surgeries, one of which was an A.L.I.F. placing titanium cages between the 3 bottom levels of my spine which turned out to be what the Surgeon referred to as a Total Collaspe and is not reversible. This surgery has been about 12 or so years ago now. Since then I have been turned over to a Pain Management Doctor. I have been on Morphine, Oxycotin, Oxycodone, as well as an implanted pain pump which I go in every 6 to 7 weeks and have this pump refilled with liquid very powerful pain medicine.
    The bottom line is it is taking higher and higher doses of all this pain medicine to assist in my daily life in order to cope with the terrible pain I am in. I in no way would ever take one pill that is not prescribed to me, although I know all this pain medicine is actually killing me but if I try to back off of it and don’t take it, I hurt beyond belief.
    That is the reason I am hoping so, so bad Tennessee will legalize medical marijania, cannibas oils , cream, gummies or whatever I can possibly use to help ease some of the terrible pain I deal with 24/7. Please someone out there give people like myself a chance to live just a little better life and stop killing my liver, lungs, and all my vital organs.I am wanting to try some of the cream just to see if it will help get me off some of the prescription medications. I would just love to be given the chance, please.

    1. Hello Emery,

      For chronic pain we recommend the 1000mg. potency oil. The topical is wonderful as well as it contains menthol so it gives an instant relief while the CBD absorbs into the skin. Our products are legal in all 50 states and you do not need a prescription or a medical card. We do recommend speaking with a physician before ingesting with other medication. Keep your eye out for our giveaways on Instagram and your email for discount codes if you have signed up for the email subscription! 🙂 We pray that you get relief soon!

  44. My dr prescribed oxycodone and Vicodin for my chronic pain fibromyalgia and other pain. I want to try the marijuana to get off the pain meds but I’m afraid if I try this and if doesn’t work I won’t be able to get my pain meds back.

    1. Hello Sheryl,

      For chronic pain we recommend the 1000mg potency. The topical is wonderful as well due to it containing menthol so it gives an instant relief while the CBD absorbs into the skin. We do recommend speaking with a physician before ingesting with other medication though, so maybe your physician will approve you trying an all natural way to relieve your pain!

    1. Hello Linda,

      Our UK office is for processing CC orders strictly. There may be small international fee(1%) on some orders, depending on your bank.

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