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What Are the Side Effects of CBD?

October 29, 2018 50 Comments

What are the side effects of CBD

It is safe to say that CBD is the latest health craze. It seems that every health food store is advocating its use, and even doctors are encouraging patients take it for a variety of different medical conditions.

The reason it’s so easy and convenient to buy, even in places wherein cannabis isn’t legal, is because it is generally considered to be food supplement. It lacks any of the addictive properties of other drugs, as well as being non-psychoactive.

If it doesn’t have side effects, it’s less of a medicine and more of a healthy addition to your life, right?

Well, that isn’t necessarily true – everything has side effects. From the food you eat to the water you drink, your body reacts in different ways to different substances. In the very same way, CBD interacts with your body and can produce unwanted side effects.

So, what are the side effects of CBD?

What is PureKana CBD?

To understand the side effects of CBD, you first need to understand what CBD is to begin with.

CBD is a cannabinoid, a substance that exists within the Cannabis sativa plant alongside its better known (and psychoactive) cousin THC.

When consumed, CBD interacts with the endocannabinoid system (ECS), a health system discovered in the 1970s and named after the plant that helped researchers find it in the first place.

This health system, which exists within all mammals, is activated through cannabinoids, both those which our own body create and those that we ingest from cannabis.

When we put cannabinoids into our bodies, the primary receptors in the ECS – CB1 and CB2 – are triggered, creating a myriad of different effects.

These effects are primarily based on where the receptors are located. A great example is that the CB1 receptors are mostly located in the brain and nervous system, meaning that, when triggered, these receptors can help diminish the feeling of pain as well as encourage the release of helpful brain neurochemicals like serotonin and melatonin.

The CB2 receptors, which are spread throughout the body, are chiefly concerned with the regeneration of cells throughout the body, as well as the inflammation response and the repair of certain cell damage.

So, when we imbibe CBD, we are essentially encouraging our bodies to heal themselves naturally, by using the same pathways and methods that we normally use to recover.

However, considering the sheer number of ways in which CBD can trigger different reactions in the body, there have to be some that are considered side effects.

What Side Effects Actually Mean

Very briefly, side effects are the unintended consequences of taking a drug.

When you take a drug – any drug – you are taking it for the purpose of receiving some sort of effect. Whether that be heart medication, insulin to control your blood sugar, or even just a calcium tablet to make your bones stronger, you are ingesting something external that your body doesn’t produce on its own, looking to change your body in some way.

However, as the human body is such a complex system, when you change one thing intentionally, it’s very likely you’ll also change other things unintentionally.

These unintentional changes are called side effects because that’s just what they are – effects that occur on the side that we didn’t want.

For example, a side effect of blood pressure medication that aims to lower your blood pressure might be that you start to get tired more easily when exerting yourself. This happens as a result of the medicine’s effects, but is still unintended.

So, let’s look at a few possible side effects of CBD that not many people might know about.

CBD & Vascular Relaxation

CBD is taken for a variety of different medical reasons, one of which is to help treat blood pressure issues.

Jadoon et al. discovered in their study that CBD helped relax the vascular walls of the circulatory system, allowing for a reduction in blood pressure that could combat the effects of high blood pressure.

While useful if you’re suffering from high blood pressure, this effect can still occur even if you don’t need a reduction in your blood pressure.

This means that, if you take CBD regularly, you might find yourself with a lower than normal blood pressure due to the cannabinoid’s ability to help relax the walls of your arteries and veins, letting the blood flow through more easily.

This isn’t particularly dangerous or deadly, but if you already suffer from low blood pressure, this can exacerbate your condition and be potentially harmful.

Potential Conflict with Prescription Drugs

This one is most pretty unknown, as it requires a bit of knowledge about how CBD is broken down to begin with.

When you consume CBD, it is carried to the liver and broken down by a complex enzyme called CYP450. This enzyme is responsible for breaking down pretty much any drug you’ve ever taken, and is thus incredibly important to your wellbeing.

This enzyme can also be disrupted in a very unusual way.

Some people might know that you shouldn’t eat grapefruit when you’re on any kind of medication; this is because grapefruit has some enzymes within it that accidentally trick the body into thinking it has enough CYP450 enzymes.

Basically, they look just like the CYP450, so the body stops making sufficient amounts of the enzyme.

When you don’t have enough of the enzyme, the drug you’ve taken will stay in your system, unable to be broken down. Then, you’ll likely take another dose of the drug later in the day, which will then be broken down by the replenished CYP450 once the body realizes it doesn’t have enough.

Then, suddenly, you might have an overdose.

This same effect occurs when you imbibe CBD; the body mistakes it for the CYP450 enzyme and can thus cause problems with other important medicine.

However, numerous studies, such as the primary study looking into the CYP450 enzyme by Bailey et al., found that the effect caused by CBD isn’t nearly as significant as with grapefruit.

This means that this side effect is only dangerous if you’re taking an extremely large amount of CBD on top of numerous forms of other medication.

Other than that, you’re likely fine.

CBD Oil & Saturated Fats – Something to Watch Out for

Though not specifically an actual side effect of CBD, it’s still important to know.

CBD is commonly ingested as part of CBD oil, meaning you will also be eating/swallowing a quantity of inert oil, usually coconut oil.

Coconut oil has a large number of useful health effects, but it is also 90% saturated fats; if you suffer from high cholesterol and take a large dose of CBD oil every day, you might be making the condition a bit worse.

To combat this, however, simply take fewer quantities of CBD oil, but with more CBD within each drop so as to minimize the amount of the oil you actually put in your system.

CBD & Unexpected Sleep Effects

CBD, as well as THC, is taken as a sleep aid to help treat patients suffering from insomnia or anxiety that stops you from sleeping.

The reason CBD has this effect is because of the interaction between CBD and the brain’s release of certain hormones. When the CB1 receptor is triggered, it causes a release of melatonin, the chemical responsible for that feeling of drowsiness that lets you fall asleep.

It stands to reason that if you take CBD – a drug that generally is used to treat insomnia, the inability to sleep – you’re going to feel sleepy, right?
Well, it’s actually a lot more complicated than that.

One study published by Rodriguez et al. found that, depending on when you actually imbibed the CBD, the effects on your sleepiness changed.

During the experiment, if CBD was taken during a period of regular wakefulness, such as during the day when you’re not physically or mentally tired, CBD was shown to actually increase awareness and the feeling of wakefulness.

However, if taken during the evening when your body is generally expecting you to be tired, it has in the inverse effect; it makes you sleepier and more prepared to go to sleep.

This fascinating result means that the side effect of CBD changes depending on your usage of it; if you take CBD during the day, it might make you a bit more alert and aware, whereas taking it at night will encourage you to go to sleep easier.

A part of CBD’s ability to make sleep easier is its pain reduction qualities, thanks to its ability to reduce inflammation and the sensation of pain.

This makes this side effect one of actual useful convenience – you can either be more aware, or more sleepy; you just need to change when you take your CBD.

Final Thoughts

CBD is, like any other drug, not entirely insular. As it affects your body, so too will your body react with it and create unexpected results.

With most medicines, you would likely find that the side effects are dangerous or otherwise irritating, but with CBD, it’s quite different.

Barring the few examples wherein a large amount of CBD might cause issues with a pre existing condition, such as low blood pressure, the side effects of CBD seem limited primarily to useful, enjoyable effects that don’t really interfere with your life.

Pain reduction, an easier time falling asleep and better blood circulation; unless you’re suffering from a very specific illness, these are generally pretty good things to suffer from.

All drugs have side effects, but CBD’s side effects seem to just be a few extra benefits thrown in for free.


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50 responses
  1. Hello, I have been diagnosed with essential tremor which makes it very difficult to write and eat. I have read that CBD oil can help with Parkinson’s and wondered if it might help with essential tremor as well. Thank you-

  2. Would CBD oil be effective in treating Benign prostatic hyperplasia and reducing the number of times needed to urinate During the night? If so when would be the best time to take it-morning or night and what dosage would be recommended?

    1. Hello,

      I am sorry, there is no definitive studies on this topic, we can not guarantee it will help. If there is any pain cbd can help alleviate pain and inflammation. We recommend speaking with your physician and hope that you find relief!

  3. Hello my husband is presently taking the CBD oil,capsules 25 mg one time a day in the morning about an hour after his ulcerative colitis medicine. Is this ok also I give him CBD for anxiety is one pill a day ok or should he take one in the evening as well . I do see a difference in him as far as anxiety. Is it ok to take if your in remission from ulcerative colitis?

    1. Hello,

      We are happy he is getting better. CBD does help with anxiety, you can slowly increase the dose if needed meaning he could take another capsule in the afternoon if needed. We do recommend speaking with a physician before ingesting with any other medication. CBD has many health benefits and can help ulcerative colitis.

  4. Am 73, have hypothyroid and have taken low dose Rx all my life. Will CBD 500 have any impact on that? If MD isn’t current on CBD use, will he be able to advise me?

    1. Hello,

      CBD can help hypothyroid, however, we do recommend speaking with physician before ingesting our products with any medication. You physician may be able to give you advice as to dosing, if not, it is best to start low and increase if/as needed.

  5. I have addisons disease and lots of pain and trouble sleeping. Would CBD be useful for me and have any affects on my adrenal insufficiency for which I take replacement steroids daily to stay alive.

    1. Hello,

      CBD can help insomnia and pain; a stronger potency is best for that. We recommend speaking with a physician about ingesting it with any medication that you take.

  6. So I am interested in trying Cbd oil…..I have a bad knee …pain all over and I don’t sleep well…..my question is I get drug and alcohol tested on job……will this come up dirty on a random test or is it safe to use….

    1. Hello,

      Sorry to hear this. 🙁 For chronic pain and insomnia a stronger potency is best. Our oils do contain .02% THC and due to the minimal amount we can not guarantee you will or will not pass a drug test as each drug screen is different. Our purepicks, gummies, and vapes are THC free.

  7. hello i have.
    really bad gout. and the pain is unbarable i take all my medication but still swollen and bad pain what would be the best dose for me to take .

    1. Hello,

      I’m very sorry to hear that! 🙁 For chronic pain the 1000mg potency is best. The recommended dose is 1/2 the dropper 1-2 times a day. If you don’t get the desired relief within a few days you can slowly increase the dose if/as needed as that is not harmful and essentially adds to the potency being absorbed. Our products metabolize differently in each individual; we do have customers whom take it in the morning, afternoon and evening as they find that is what works best for them. The topical ointment may be beneficial as well as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

  8. I have an injury to my back and neck, herniated disc and severe nerve pain that goes down my leg and arms. I’m tying to avoid another surgery, but the pain is really bad. I do pain management, injections etc. it’s not enough for the pain. I don’t know what cbd is best to use. I have used 125 mg cbd lotion and gummies but it does nothing.

    1. Hello,

      A stronger potency is best. The 1000mg potency oil would be best for your pain. The topical ointment may be beneficial as well as it gives an instant relief while the CBD absorbs into the skin. I hope this helps you and that you start to get relief!

  9. Can CBD oil (Purekana 1000mg) cause an allergic reaction like red spots and itching? Would taking Excedrin on the same day as the CBD cause this to happen?

    1. Hello,

      It may, our products metabolize differently in each individual. We recommend speaking to a physician before ingesting with any medication. We hope that it starts to help you without causing red spots and itchiness. Please feel free to email us with any questions or concerns Ann.

  10. What dosage do you recommend for anxiety/panic attacks? I don’t want to be too sleepy during the day, as I have 3 children but at night that would be great. Thanks.

    1. Hello,

      It is best to start low and slowly increase if/as needed. Start with the 300mg potency. The recommended dose is 1/2 the dropper 1-2 times a day. If you do not get the desired relief within a few days you can slowly increase the dose if/as needed. Our products metabolize differently in each individual; some take it in the morning, afternoon, and evening as they find that is what works best for them.

  11. Have fibromyalgia for 20 years. Down to 1/2 pill in AM. Severe muscle pain and fatigue. On meds for high blood pressure but will soon be out. Never tried this but need help. Finances restrict me from Dr. visits. Any advice would be greatly appreciated.

    1. Hello,

      We are very sorry to hear this. 🙁 CBD can help chronic pain and inflammation. A stronger potency is best in these situations. The recommended dose is 1/2 the dropper 1-2 times a day. If you do not get the desired relief within a few days you can slowly increase the dose if/as needed. Our products metabolize differently in each individual; some take it in the morning, afternoon, and evening as they find that is what works best for them. The topical ointment may be beneficial for you as well as it contains menthol so it gives an instant relief while the CBD absorbs into the skin. Make sure to sign up for the email subscription to receive coupon codes and we really hope that you are able to get relief!

    1. Hello,

      We recommend speaking to a physician before ingesting with any medication. CBD can lower your blood pressure so it may be good to speak with your physician first.

  12. My relatives every time say that I am wasting my time here at net, but I know I am getting knowledge all the time by reading thes nice articles or reviews.

  13. My Mate is off Rx after years of them messing up her body and giving her Dementia. Her dose is 1000 mg once a day along with a really nutritious diet.of fruits, nuts and veggies. We also make our own “Pecan milk” for smoothies.

  14. I have DID and have a lot of pain, swelling and stiffness in my thumb and wrist. I am scheduled for surgery in several weeks for this and would like to use CBD oil now and post operative. What dosage should I purchase.

    1. Hello,

      A stronger potency oil would be best. The recommended dose is 1/2 the dropper 1-2 times a day. If you do not get the desired relief within a couple days you can slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. Our products metabolize differently in each individual; we do have customers whom take it in the morning, afternoon, and evening as they find that is what works best for them. The topical ointment may be beneficial as well, however, we do not recommend putting it on any open wounds.

    1. Hello,

      The 1000mg would be best. The recommended dose is 1/2 the dropper 1-2 times a day. If you do not get the desired relief within a couple days you can slowly increase the dose as that is not harmful and essentially adds to the potency being absorbed. Our products metabolize differently in each individual; we do have customers whom take it in the morning, afternoon, and evening as they find that is what works best for them. The topical ointment may be beneficial as well as it contains menthol so it gives an instant relief while the CBD absorbs into the skin.

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